Description

What is Triclabend 500Mg Tablet?

Triclabend 500Mg, an anthelmintic medication, is utilized for the treatment and management of fascioliasis, which is a kind of infection occurring due to liver fluke parasites or flatworms.

The active component present in Triclabend 500 Mg is triclabendazole.

What is the Use of Triclabend 500 Mg Tablet?

Triclabend 500 Mg Tablet is an anthelmintic or anti-parasitic medicine that contains the primary component triclabendazole and is primarily used in the treatment of Fascioliasis that occurs from Fasciola hepatica (caused by the liver fluke parasite).

Triclabendazole, used for decades and approved by the FDA in 2019 for use in humans in the treatment of fascioliasis, is effective in targeting and killing the parasites that survive and grow in the bile ducts or liver. Belonging to the benzimidazole anthelmintic, it is a prescription medicine that should be taken in suitable doses and duration.

Triclabendazole 250Mg helps damage the microtubules of parasites, starves them, and leads to their death. It is also used for the treatment of Paragonimiasis, indicated by infections caused by the lung fluke.

Benefits of Triclabend 500mg

The primary benefit of Triclabend 500mg is that it targets and kills Fasciola hepatica as well as the Fasciola gigantica flatworms that affect both the bile ducts and the liver adversely.

Triclabendazole 500Mg is known to be highly effective against not just adult stages of harmful liver flukes but also targets immature stages successfully. As a result, further growth of the infection is stopped, and the recurring damage to the liver is controlled.

Since most patients recover after only two doses, this single-day treatment has a higher cure rate of 90-100% which makes Triclabend 500Mg one of the most effective antiparasitic drugs used for dealing with fascioliasis.

The efficacy of the medicine has also been recognized by WHO that is involved with the donation of triclabendazole for the management of parasitic infections like fascioliasis to be delivered in endemic countries.

How Does Triclabend 500 Mg Work?

• Triclabend 500 Mg inhibits the energy production of the parasites and prevents their cellular structures from forming, causing them to starve and die.
• The glycolytic pathway is affected, and the inhibition of microtubule formation happens; it is an important process for the growth and development of parasite cells, which needs to be stopped to disrupt the growth.
• Flatworms are targeted and subsequently killed, as a result of which fascioliasis and other forms of parasitic infections are controlled.
• Fasciola hepatica, the flatworms causing fascioliasis, are targeted and killed completely.

How to Take Triclabend 500mg Tablet?

When using Triclabend 500mg for fascioliasis, it should usually be taken in two doses that are spaced 12 hours apart from each other.

Patients may also take the dose of Triclabend 500 Mg with food if they feel they need to improve absorption too.

Patients who find it problematic to swallow the medicine may crush and use it with a meal if the doctor suggests so, but intake of the same meal should be complete within 4 hours.

How Long Does Triclabend 500mg Last?

Triclabend 500mg contains triclabendazole that starts working within the body in a few hours. The action and mechanism of killing the liver fluke parasite may continue for 1-2 days after the patient has taken the last dose.

The half-life of triclabendazole is approximately 8-12 hours. The sulphoxide formation lasts for 20 or 30 hours. Hence, the medicine may continue its mechanism within the body for the next 1 or 2 days.

It is a single-day treatment, and the action is completed in a day, with the recommended dose divided into two, taken after 12 hours.

Improvement can be seen in 28-48 hours as symptoms like discomfort, fever, and pain tend to reduce. A few points to note regarding the mechanism of this drug are:

• Inflammation in the liver starts settling down in 1 or 2 weeks.
• Complete recovery of the liver may take weeks.
• Liver flukes are usually killed within a duration of 1 or 2 days.
• Liver tests and stool tests may show positive signs only after 2 or 3 weeks.

Dosage

Triclabend 500mg is a prescription medicine that should be used within an appropriate dose or duration. Typical administration of this medicine is a single or dual dose of 10 mg/kg. It may be suggested to use the medicine with fatty meals so that the absorption can be improved.

A healthcare professional can prescribe a precise and suitable dose according to the body weight. Most patients start getting better or recover completely after two doses only, which makes it convenient and an easy and safe drug formulation to follow.

Side-Effect

Common side effects of Triclabend 500mg may include the following:

• Painful stomach
• Vomiting
• Nausea
• Reduced appetite
• Diarrhea
• Fever
• Heavy or increased sweating
• Light-headedness
• Fever
• Itching
• Skin rash
• Hives

Severe side effects of Triclabendazole 500Mg may include:

• Allergies
• Changes in cardiac rhythms
• Liver problems
• Breathlessness

Most of these side effects are a result of an immune reaction or temporary inflammation caused in the bile ducts or liver due to the starvation and death of the parasites.

Precautions of Triclabend 500mg

• Monitoring: Doctors may recommend blood tests or an ECG to find out more about the unpleasant effects, particularly on cardiac rhythm and liver function.
• Liver/kidney: Do not overlook to update your medical professional in case of any liver or kidney problems or heart problems.
• Breastfeeding/pregnancy: The history of QT prolongation should also be discussed for breastfeeding or pregnant women.
• Intake: Take the dose of Triclabendazole 500Mg with food so that any likelihood of an upset stomach can be prevented.
• Treatment: Skipping or avoiding the dose is not recommended for promising results. Finish the treatment without stopping the dose of the drug, even when you gradually start feeling better.
• Prescription drug: Use Triclabendazole 500Mg under stringent medical administration. No self-medication allowed.
• Liver: The medicine is normally processed within the liver; hence, along with dose adjustment, inform your doctor in case of liver problems like fatty liver, hepatitis, and cirrhosis.
• Impact: When the parasites starve and die, patients experiencing bile duct blockage, Cholangitis, and Gallstones may witness unusual and stronger reactions.
• Cardiac: Triclabendazole 500Mg is capable of affecting cardiac rhythm (although rare), hence patients with a history of improper heart rate, long QT intervals, and cardiac rhythm disorders need to discuss their condition with their doctor.
• Allergies: Patients allergic to triclabendazole may choose to avoid it.
• Pediatric use: Triclabendazole 500Mg is to be used with caution in children under 6 years, as the safety of this drug for the pediatric group has not been completely established as of now.
• Driving: Avoid driving as symptoms like fatigue, blurred vision, and dizziness may occur.
• Overuse: Overuse of the medicine may have adverse effects on the liver; hence, avoid repeating the dose of the medicine unless prescribed.

Drug interactions

Drug interactions of Triclabend 500Mg are possible with antacids, drugs affecting liver enzymes such as phenytoin, rifampicin, and carbamazepine.

Avoid excess alcohol for 24-48 hours during the intake of this medicine, as it may stress the liver, and adverse symptoms may increase.

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